Although 80–90% of adults are seropositive for antibodies against the human parvovirus adeno‐associated virus (AAV), infection has not been associated with either symptoms or disease. In cell culture, AAV infection is not productive unless there is a coinfection with a helper virus, either adenovirus or any type of herpes virus; in the absence of a helper virus coinfection the viral genome is integrated into the genome, usually at a specific site on chromosome 19q13.3‐qter. The integrated genome can be activated and (...) rescued by subsequent super infection by a helper virus. The high frequency of site‐specific integration by AAV and the lack of associated disease have encouraged the use of AAV as a vector for gene therapy. This review will focus on the molecular mechanisms involved in the establishment of, and rescue from, the latent state and their relevance to use of AAV as a vector. (shrink)

Anselm’s ontological argument for the existence of God is examined. It is concluded that Anselm errs in assuming the greatest "thing" must be a sentient being. The existence of God, then, is not established by Anselm’s argument, and is concluded to be unlikely for other reasons as well, one being that a perfected sentient being would be a logical impossibility. An afterlife and personal immortality are not precluded however; these goals could be reached by future scientific means. For now cryonics (...) is advocated as a means to reach a more advanced future when death may be physically overcome. (shrink)

This study is an examination of the manner in which intelligence mediates desire. Its central claims are that all desire is necessarily determined as such by the capacity of intelligence and that the specific quality of desire as animal or human is therefore conditioned by the specific power of intelligence possessed by the desiring creature. In looking at human desire, it is further argued that the presence of rational intelligence introduces instability in the natural soul that in turn conditions its (...) desire as potentially unreasonable and reasonable. Developing this argument first in light of Aristotle's moral psychology, attention is then turned to Hegel's philosophical psychology, as found in his Philosophy of Mind, and to his account of desire, as it is found in his Phenomenology of Spirit. By examining sections of these works, it is shown that Hegel revives significant aspects of this classical account of moral psychology and desire, which have for the most part been neglected in modern philosophical psychology. It is also suggested, however, the Hegel introduces significant variations to this classical view in his appropriation of it that have rendered him vulnerable to much of the post-modern criticism that he has received. (shrink)

The author reviews the literature in professional education that cites Ernest Becker’s work from the 1960s-70s. Some of Becker’s main ideas from his own writing on education are also reviewed. The purpose here is to establish a sketch, not a full-study, of the importance of Becker’s educational legacy and begin some critique of the biases of professional educators in regard to utilizing Becker’s work. This critical reflectivity is an appropriate model of Becker’s own integrative approach to knowledge and learning. The (...) aim is to ensure that future applications may be cautious to certain reductive tendencies and offer more diverse perspectives that are truer to Becker’s oeuvre and core ideas about human behavior and societies in general, and education specifically. The author concludes that the future of Education, formal and informal, would do well to take a long serious look at Becker’s work, especially as the world’s children, youths and adults are is becoming more and more vulnerable to frightening conditions, with cascading collapse of systems, including extinctions of all kinds already well underway in an era of global threats nearing extremes. Becker’s oeuvre is both realistic and idealistic, offering Education a way to radically improve to help make for a better world. (shrink)

In this paper, we set out a basic approach to the modeling of narrative in interactive virtual worlds. This approach adopts a bipartite model taken from narrative theory, in which narrative is composed of story and discourse. In our approach, story elements — plot and character — are defined in terms of plans that drive the dynamics of a virtual environment. Discourse elements — the narrative’s communicative actions — are defined in terms of discourse plans whose communicative goals include conveying (...) the story world plan’s structure. To ground the model in computational terms, we provide examples from research under way in the Liquid Narrative Group involving the design of the Mimesis system, an architecture for intelligent interactive narrative incorporating concepts from artificial intelligence, narrative theory, cognitive psychology and computational linguistics. (shrink)

text as original form and reprinted in 2020.

Uteroferrin, a purple‐colored, iron‐containing acid phosphatase, with many of the properties of a lysosomal hydrolase, transports iron from the mother to the conceptus in pregnant pigs. Uteroferrin, however, is but one member of what may be a broad class of iron‐containing phosphatases with unusual spectral properties which result from a novel type of di‐iron active site. The biological function of uteroferrin is unknown. We argue here that the in vivo function of uteroferrin, despite its undoubted ability to act as a (...) potent acid phosphatase, is that of a transplacental iron transporter. (shrink)

Laboratory-based studies of problem solving suggest that transfer of solution principles from an analogue to a target arises only minimally without the presence of directive hints. Recently, however, real-world studies indicate that experts frequently and spontaneously use analogies in domain-based problem solving. There is also some evidence that in certain circumstances domain novices can draw analogies designed to illustrate arguments. It is less clear, however, whether domain novices can invoke analogies in the sophisticated manner of experts to enable them to (...) progress problem solving. In the current study groups of novices and experts tackled large-scale management problems. Spontaneous analogising was observed in both conditions, with no marked differences between expertise levels in the frequency, structure, or function of analogising. On average four analogies were generated by groups per hour, with significantly more relational mappings between analogue and target being produced than superficial object-and-attribute mappings. Analogising served two different purposes: problem solving (dominated by relational mappings), and illustration (which for novices was dominated by object-and-attribute mappings). Overall, our novices showed a sophistication in domain-based analogical reasoning that is usually only observed with experts, in addition to a sensitivity to the pragmatics of analogy use. (shrink)

We support the ambitious goal of unification within the behavioral sciences. We suggest that Darwinian evolution by means of natural selection can provide the integrative glue for this purpose, and we review our own work on selective investment theory (SIT), which is an example of how other-regarding preferences can be accommodated by a gene-centered account of evolution. (Published Online April 27 2007).

The author, with over three decades of focused research on fear and fearlessness and 45 years as an emancipatory educator, argues that philosophy and philosophy of education have missed several great opportunities to help bring about theoretical and meta-perspectival clarity, wisdom and compassion, and practical ways to the sphere of fear management/education (FME) throughout history. FME is not simple, nor a luxury, it is complex. It's foundational to good curriculum but it requires careful philosophical critique. This book embarks on a (...) unique transdisciplinary understanding of The Fear Problematique and how it can be integrated as a pivotal contextual reference for assessing the 'best' way to go in Education today and tomorrow. Educational philosophy is examined and shown to have largely 'missed the boat' in terms of responding critically and ethically to the insidious demand of having to truly educate ourselves when we are so scared stiff. Such a state of growing chronic fear, of morphing types of fear, and a culture of fear, ought to be central in shaping a philosophy of fear(ism) for education. The book challenges all leaders, but especially philosophers and educators, to upgrade their own fear imaginary and fear education for the 21st century, a century of terror likely to grow in the cascading global crises. (shrink)

The Theory Theory (TT) versus Simulation Theory (ST) debate is primarily concerned with how we understand others’ mental states. Theory theorists claim we do this using rules that are akin to theoretical laws, whereas simulation theorists claim we use our own minds to imagine ourselves in another’s position. Theorists from both camps suggest a consideration of individuals with autism spectrum disorders (ASD) can help resolve the TT/ST debate (e.g., Baron-Cohen 1995; Carruthers 1996a; Goldman 2006). We present a three-part argument that (...) such research has so far been inconclusive and that the prospects for studies of ASD to resolve the debate in the near future remain uncertain. First, we discuss evidence indicating that some individuals with ASD can perform effectively on tests of mental state understanding, which questions what ASD can tell us regarding theorising or simulation. Second, we claim that there is compelling evidence that domain-general mechanisms are implicated in mental state reasoning, which undermines how ASD might inform the TT/ST debate given that both theories appeal to domain-specific mindreading mechanisms. Third, we suggest that neuroscientific evidence for an assumed role of the mirror neuron system in autism also fails to arbitrate between TT and ST. We suggest that while the study of ASD may eventually provide a resolution to the TT/ST debate, it is also vital for researchers to examine the issues through other avenues, for example, by examining people’s everyday counterfactual reasoning with mental state scenarios. (shrink)

The viewpoint that consciousness, including feeling, could be fully expressed by a computational device is known as strong artificial intelligence or strong AI. Here I offer a defense of strong AI based on machine-state functionalism at the quantum level, or quantum-state functionalism. I consider arguments against strong AI, then summarize some counterarguments I find compelling, including Torkel Franzén’s work which challenges Roger Penrose’s claim, based on Gödel incompleteness, that mathematicians have nonalgorithmic levels of “certainty.” Some consequences of strong AI are (...) then considered. A resolution is offered of some problems including John Searle’s Chinese Room problem and the problem of consciousness propagation under isomorphism. (shrink)

In this article I interpret the conversation that takes place between Socrates and Polemarchus in Book One of the Republic according to its dramatic logic by examining the rhetorical artfulness that informs Socrates’ argumentative tactics. After first examining Polemarchus’s character as obedient spiritedness, I then turn to the argument, showing that Socrates does not undermine Polemarchus’s original opinion but, rather, by making legitimate use of the analogy between justice and technē, moves him to attend to the useful knowledge implicit in (...) his understanding of friendship, a knowledge by virtue of which he will be a more responsive guardian of what he values. Finally, I contend that Socrates enacts the definition of justice in question and indirectly argues for his own just art of rhetoric, which he employs in conversation with Polemarchus in his aim to be responsible to political life and to do it some good. (shrink)

For all the time and effort expended on empowerment and participation ‘programmes’, many fail each year. This paper argues that the cause is a faulty view of communication widespread among managers and their teachers: the conduit, transmission model. It frustrates participation and is an ideology of management control. It rests on untenable beliefs about meaning and how language relates to the world. The paper proposes a new model of communication in terms of ‘communicating other/wise’ and offers examples of how it (...) can be practised in management education and by managers aiming to bring empowered and participatory workplaces into being. (shrink)

In An Essay in Aid of a Grammar of Assent, John Henry Newman articulates his fundamental philosophical orientation by giving priority to real apprehension over notional apprehension. He distinguishes between the two by saying that notional apprehension hasto do with things internal to the mind and admits of exactness and clarity whereas real apprehension has to do with things external to the mind and does not admit of the same degree of clarity and exactness. I argue that the connection between (...) “inside the mind” and “clarity and exactness” lies in the constructive activity underlying notional thinking. Real apprehension, on the other hand, involves a given apprehension of unity, mainly, the concrete unity of intelligent life, which includes but cannot be reduced to the constructive activity of notional thinking. Thus, I argue, Newman’s realism undercuts any form of modern transcendentalism and evinces a form of classical human realism. (shrink)

Abraham’s Luggage: A Social Life of Things in the Medieval Indian Ocean World By LambournElizabeth A., xvi + 301 pp. Price HB £75.00. EAN 978–1107173880.

Twenty-five years ago Israel Scheffler argued for the inclusion of philosophy of science in the preparation of science teachers. It was part of his wider argument for the inclusion of courses in the philosophy of the discipline in programmes that are preparing people to teach that discipline. For the most part Scheffler's suggestion, at least as far as science education is concerned, went unheeded. Pleasingly, in recent times there has been some rapprochement between these fields. This paper will restate parts (...) of Scheffler's argument, it will develop some additional considerations pertaining to it, and it will set the discussion in the context of contemporary debate about science, science education and teacher training. With changed time and circumstances, Scheffler' arguments might find more adherents than when they were initially proposed. My revision of Scheffler's argument has two planks: first pedagogical, second professional. (shrink)

Strong arguments are presented by Hargrave suggesting that the crystallization of visual rhodopsin for high resolution analysis by X-ray crystallography or electron microscopy is feasible. However, the effort needed to achieve this goal will most likely exceed the resources of a single laboratory and a concerted approach to the research is necessary.

In order to survive, the developing conceptus must interrupt the normal ovarian cycle of the mother and extend the production of progesterone by the corpus luteum. An unusual Type 1 interferon (IFN), related structurally to the IFN–α molecule and produced in massive amounts for only a few days by the first epithelium (trophectoderm) of the preimplantation conceptus, has been implicated as the antiluteolytic agent in sheep and cattle. IFN‐a therapy during this critical period can also improve pregnancy success in sheep. (...) It remains unclear, however, whether the trophoblast IFN have specialized biological properties or whether they are unique merely in the timing, magnitude and site of their expression. (shrink)

The goal of this article is to outline a new account of the virtue of patience. To help build the account, we focus on five important issues pertaining to patience: (i) goals and time, (ii) emotion, (iii) continence versus virtue, (iv) motivation, and (v) good ends. The heart of the resulting account is that patience is a cross-situational and stable disposition to react, both internally and externally, to slower than desired progress toward goal achievement with a reasonable level of calmness. (...) The article ends with an application of the account to better understanding the vices associated with patience. (shrink)

This book contains new work on character from the perspectives of philosophy, theology, and psychology. From a virtual reality simulation of the Milgram shock experiments, to understanding the virtue of modesty in Muslim societies, to defending soldiers’ moral responsibility for committing war crimes, these chapters break new ground and significantly advance our understanding of character. The main topics covered fall under the heading of our beliefs about character, the existence and nature of character traits, character and ethical theory, virtue epistemology, (...) the nature of particular virtues, character development, and challenges to character and virtue from neuroscience and situationism. The book significantly shapes discussions of character in scholarship. (shrink)

Depue & Morrone-Strupinsky (D&M-S) do not address how a reward system accommodates the motivational dilemmas associated with (a) the decision to approach versus avoid conspecifics, and (b) self versus other tradeoffs inherent in behaving altruistically toward bonded relationship partners. We provide an alternative evolutionary view that addresses motivational conflict, and discuss implications for the neurobiological study of affiliative bonds.

The network approach proposed by Cramer et al. suggests fascinating new directions of research on mental disorders. Research is needed to find evidence for the causal power of symptoms, to examine symptoms thoroughly, to investigate individual differences in edge strength, to discover etiological processes for each symptom, and to determine whether and why symptoms cohere into distinct mental disorders.

The rise of precision medicine has led to an unprecedented focus on human biological material in biomedical research. In addition, rapid advances in stem cell technology, regenerative medicine and synthetic biology are leading to more complex human tissue structures and new applications with tremendous potential for medicine. While promising, these developments also raise several ethical and practical challenges which have been the subject of extensive academic debate. These debates have led to increasing calls for longitudinal governance arrangements between tissue providers (...) and biobanks that go beyond the initial moment of obtaining consent, such as closer involvement of tissue providers in what happens to their tissue, and more active participatory approaches to the governance of biobanks. However, in spite of these calls, such measures are being adopted slowly in practice, and there remains a strong tendency to focus on the consent procedure as the tool for addressing the ethical challenges of contemporary biobanking. In this paper, we argue that one of the barriers to this transition is the dominant language pervading the field of human tissue research, in which the provision of tissue is phrased as a ‘donation’ or ‘gift’, and tissue providers are referred to as ‘donors’. Because of the performative qualities of language, the effect of using ‘donation’ and ‘donor’ shapes a professional culture in which biobank participants are perceived as passive providers of tissue free from further considerations or entitlements. This hampers the kind of participatory approaches to governance that are deemed necessary to adequately address the ethical challenges currently faced in human tissue research. Rather than reinforcing this idea through language, we need to pave the way for the kind of participatory approaches to governance that are being extensively argued for by starting with the appropriate terminology. (shrink)

Uncoupling proteins (UCPs) regulate mitochondrial function, and thus cellular metabolism. Angiotensin‐converting enzyme (ACE) is the central component of endocrine and local tissue renin–angiotensin systems (RAS), which also regulate diverse aspects of whole‐body metabolism and mitochondrial function (partly through altering mitochondrial UCP expression). We show that ACE expression also appears to be regulated by mitochondrial UCPs. In genetic analysis of two unrelated populations (healthy young UK men and Scandinavian diabetic patients) serum ACE (sACE) activity was significantly higher amongst UCP3‐55C (rather than (...) T) and UCP2 I (rather than D) allele carriers. RNA interference against UCP2 in human umbilical vein endothelial cells reduced UCP2 mRNA sixfold (P < 0·01) whilst increasing ACE expression within a physiological range (<1·8‐fold at 48 h; P < 0·01). Our findings suggest novel hypotheses. Firstly, cellular feedback regulation may occur between UCPs and ACE. Secondly, cellular UCP regulation of sACE suggests a novel means of crosstalk between (and mutual regulation of) cellular and endocrine metabolism. This might partly explain the reduced risk of developing diabetes and metabolic syndrome with RAS antagonists and offer insight into the origins of cardiovascular disease in which UCPs and ACE both play a role. (shrink)

Die gegenwartigen Herausforderungen des internationalen Verhaltnisses sind Gemeingut: Gewalt zwischen und in Staaten, Bedrohung durch Massenvernichtungswaffen, der zunehmende globale Wirtschaftsverkehr. Durch sie ist souverane Staatlichkeit als Kern politischer Handlungsoptionen, rechtlicher Begriffsbildung und ihrer wissenschaftlichen Erfassung problematisch geworden. Oft erscheint der Ruckzug auf staatliche Selbstbehauptung oder die Einrichtung einer globalen Zwangsgewalt als einzige Losung. Welches Potential im Gegensatz dazu in dem auf Kant zuruckgehenden Gedanken internationaler Kooperation liegt, untersuchten Vertreter verschiedener Fachrichtungen im Rahmen der im Band dokumentierten interdisziplinaren Tagung des Seminars (...) fur Rechtsphilosophie an der Universitat Hamburg.". (shrink)